Same proven KRYSTEXXA.
Half the clinic visits.
Horizon Therapeutics is studying whether KRYSTEXXA (pegloticase), an IV treatment for gout, can be given once every 4 weeks instead of the current every 2 weeks, while maintaining similar effectiveness. This schedule may reduce the number of visits required. Compensation is available for time and travel.
Total IV infusions over approx. 12 months
Compensation provided for time & travel
Spots available across US sites
All study care, exams & lab tests
Who may be a good fit for this study?
This study is designed for adults whose gout has been difficult to control even after trying standard medications. Below are the key things that may (or may not) apply to you.
Adults 18 years or older
This study is open to any adult man or woman aged 18 and above.
Gout that hasn't responded to standard pills
Your gout continues despite trying medications like allopurinol or febuxostat at the highest dose your doctor recommended or, you can't take those medications for medical reasons.
Recent gout attacks or visible lumps
You've had 2 or more gout flares in the past year, or you have visible chalky lumps (called tophi) caused by uric acid crystals building up under the skin.
Weight under 352 lbs (160 kg)
The study medication has been tested and dosing is calibrated safely for people within this weight range.
Recent serious heart events
People who were hospitalized for heart failure, or treated for a heart attack or serious unstable chest pain in the past 3 months, cannot join for safety reasons.
Long-term strong immune-suppressing medication
People currently taking immune-suppressing drugs like azathioprine or mycophenolate, or high-dose steroids (prednisone over 10 mg daily for 3 months or more), are not eligible at this time.
You can be compensated for your time
All gout-related care during the study is completely covered — no out-of-pocket costs, and no health insurance required. You'll also receive compensation for your time and any travel involved in attending visits.
Out-of-pocket cost
for all study care
Built on science. Backed by a global sponsor.
This study follows established clinical research guidelines to protect your safety, privacy, and rights at every step.
Sponsored by Horizon Therapeutics
A global biopharmaceutical company sponsoring this study to evaluate a treatment approach for adults living with difficult-to-control gout.
Registered and Regulated
This Phase 4 clinical study is conducted under an approved protocol and follows established clinical research and safety standards.
Reviewed by Independent Ethics Committees
An external review ensures the study is appropriate and that participant rights are protected.
Qualified Research Sites
Conducted at clinical research centers staffed by trained medical professionals experienced in clinical studies.
Voluntary Participation
Taking part is voluntary. You may withdraw at any time without penalty or loss of benefits to which you are otherwise entitled.
Your Privacy Matters
DecenTrialz securely handles your information during the pre-screening process. Your data is kept confidential and managed in accordance with applicable privacy regulations.
Answer 5 questions to see if you could qualify
+1What to expect, step by step
Here's a clear, plain-language picture of what happens if you decide to get involved:
Online eligibility check
Answer 5 short questions on this page, no forms, no commitment. If your answers suggest you might be eligible, a Decentrialz coordinator will reach out within 3 working days for a no-obligation phone call.
Medical screening & preparation
You'll visit the clinic in Chicago for a thorough health review, blood tests, a physical exam, and an ECG. If all looks good, you'll start a weekly oral medication for 4 weeks to prepare your immune system for the main treatment phase.
Treatment period
You'll receive IV infusions of the study medication at the clinic, roughly every 2 or 4 weeks depending on the group you're assigned to. Each session lasts about 2 hours. You continue the weekly oral medication throughout. During the second half, everyone receives the every-4-week schedule.
Safety follow-up
After your last infusion, the team will check in by phone or email 30 days later. Then, about 3 months after your final dose, you'll come in for one last safety visit at the clinic. After that, you're done!
Finding the Right clinical trial shouldn't feel overwhelming.
DecenTrialz helps you discover clinical trials that fit your condition, location, and needs without the guesswork. We combine smart technology with real human support so you can understand your options, check eligibility, and take the next step with confidence. No medical jargon. No endless searching. Just a clear path forward.
Finding the
Right clinical trial shouldn't feel overwhelming.
DecenTrialz helps you discover clinical trials that fit your condition, location, and needs without the guesswork. We combine smart technology with real human support so you can understand your options, check eligibility, and take the next step with confidence. No medical jargon. No endless searching. Just a clear path forward.
Take two minutes, it could change how you manage your gout.
No obligation, no commitment. Just 5 questions to see if this study could be right for you.
